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| Year | Name / Event | Description |
|---|---|---|
| 06-04-1580 | 1580 Dover Straits earthquake | One of the largest earthquakes recorded in the history of England, Flanders, or Northern France, takes place. |
| 09-11-1580 | Second Desmond Rebellion | Second Desmond Rebellion: The Siege of Smerwick ends with the Catholic garrison surrendering to the English forces under Arthur Grey. The majority of the garrison is massacred the next day. |
| 10-10-1580 | Kingdom of Ireland | Over 600 Papal troops land in Ireland to support the Second Desmond Rebellion. |
| 12-07-1580 | Ostrog Bible | The Ostrog Bible, one of the early printed Bibles in a Slavic language, is published. |
| 25-08-1580 | War of the Portuguese Succession | War of the Portuguese Succession: Spanish victory at the Battle of Alcântara brings about the Iberian Union. |
| 26-09-1580 | Francis Drake | Francis Drake finishes his circumnavigation of the Earth in Plymouth, England. |
